Dopamine transporter threonine-53 phosphorylation dictates kappa opioid receptor mediated locomotor suppression and conditioned place aversion via transporter upregulation
D. Ragu Varman, L. D. Jayanthi, S. Ramamoorthy
This study shows that phosphorylation of dopamine transporter at threonine-53 (pT53-DAT) mediates KOR agonist-induced locomotor suppression and aversion by enhancing DAT activity and surface expression.
bioRxiv · May 9, 2024 · PreprintAnimal Behavior & Cognition