Nickel-Sulfonate Mode of Substrate Binding for Forward and Reverse Reactions of Methyl-SCoM Reductase Suggest a Radical Mechanism Involving Long Range Electron Transfer
A. Patwardhan, R. Sarangi, B. Ginovska, S. Raugei, S. W. Ragsdale
This paper identifies that methyl-SCoM and CoMSSCoB bind to Ni(I) in MCR via sulfonate groups, not sulfur, and proposes long-range electron transfer as the mechanism for methane synthesis and oxidation.
bioRxiv · Jan 25, 2021Biochemistry