A. Patwardhan

Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions

This study identifies venom-derived SSTR4 agonists as potential non-opioid therapeutics for peripheral pain conditions.

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

This study investigates the role of TgLaforin, a glucan phosphatase, in Toxoplasma gondii by showing its impact on glucan metabolism, virulence, and bradyzoite survival during chronic infection.

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

The paper identifies somatostatin venom analogs from fish-hunting cone snails, showing their potential as therapeutic leads for pain, cancer, and endocrine disorders.

aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis

This study identifies a novel β-arrestin-2-mediated signaling pathway that mediates aPC/PAR1's anti-apoptotic effects in endothelial cells.

Nickel-Sulfonate Mode of Substrate Binding for Forward and Reverse Reactions of Methyl-SCoM Reductase Suggest a Radical Mechanism Involving Long Range Electron Transfer

This paper identifies that methyl-SCoM and CoMSSCoB bind to Ni(I) in MCR via sulfonate groups, not sulfur, and proposes long-range electron transfer as the mechanism for methane synthesis and oxidation.

The ratio versus difference optimization and its implications for optimality theory

The paper compares ratio and difference optimization models, identifying conditions under which each is appropriate and applies them to various biological and economic examples.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.