SIRT5 is the desuccinylase of LDHA as novel cancer metastatic stimulator in aggressive prostate cancer
O. K. Kwon, I. H. Bang, S. Y. Choi, J. M. Jeon, A. Y. Na, Y. Gao, S. S. Cho, S. H. Ki, Y. Chpe, J. N. Lee, Y.-S. Ha, E. Bae, T. G. Kwon, B.-H. Park, S. Lee
This study identifies SIRT5 as a desuccinylase that regulates LDHA succinylation, promoting prostate cancer metastasis and progression.
bioRxiv · Aug 8, 2021Cancer Biology