High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
S. S. Dhakar, A. Galera-Prat, L. Lehtiö
This study develops a FRET-based high-throughput screening assay to identify inhibitors of PARP1/2-HPF1 interaction, discovering two compounds with μM potency.
bioRxiv · Nov 14, 2023Biochemistry