Acute phase protein, α-1-acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.
S. S. Mosale, K. V. Abhilasha, S. P. Jacob, V. H. Chaithra, V. Basrur, B. Willard, T. M. McIntyre, K. S. Prabhu, G. K. Marathe
This study shows AGP-1 enhances TLR-2 but not TLR-4 mediated inflammatory responses in vitro and in vivo, suggesting a role in sepsis pathobiology.
bioRxiv · May 16, 2019Immunology