Author

T. M. McIntyre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. K. Marathe· 2 shared K. V. Abhilasha· 2 shared R. Chen· 2 shared S. P. Jacob· 2 shared V. Basrur· 2 shared A. A. Khorana· 1 shared A. Aggarwal· 1 shared A. Jimenez-Pascual· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

G. K. Marathe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19

A. Aggarwal, T. K. Singh, M. Pham, M. Godwin, R. Chen, T. M. McIntyre, M. K. Chung, C. Jennings, M. Ali, H. Park, K. Englund, A. A. Khorana, L. Svensson, S. R. Kapadia, K. R. McCrae, S. J. Cameron

This study examines platelet function and thrombotic risk in PASC patients, finding dysregulated platelet responses and reduced thrombosis under shear conditions.

bioRxiv · Jun 18, 2023 · PreprintPharmacology & Toxicology

Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity.

M. S. Sumanth, S. P. Jacob, K. V. Abhilasha, B. K. Manne, V. Basrur, S. D. Lehoux, R. A. Campbell, C. C. Yost, M. T. Rondina, T. M. McIntyre, R. D. Cummings, A. S. Weyrich, G. K. Marathe

This study shows that differential glycosylation of AGP-1 leads to distinct functional effects on neutrophils and platelets during inflammation.

bioRxiv · Feb 27, 2020Biochemistry

Acute phase protein, α-1-acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

S. S. Mosale, K. V. Abhilasha, S. P. Jacob, V. H. Chaithra, V. Basrur, B. Willard, T. M. McIntyre, K. S. Prabhu, G. K. Marathe

This study shows AGP-1 enhances TLR-2 but not TLR-4 mediated inflammatory responses in vitro and in vivo, suggesting a role in sepsis pathobiology.

bioRxiv · May 16, 2019Immunology

ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells

J. S. Hale, A. Jimenez-Pascual, A. Kordowski, J. Pugh, S. Rao, D. J. Silver, T. Alban, D. B. Watson, R. Chen, T. M. McIntyre, G. Colombo, G. Taraboletti, K. O. Holmberg, K. Forsberg-Nilsson, J. D. Lathia, F. Siebzehnrubl

This study identifies a novel signaling loop involving ADAMDEC1 and FGF2/FGFR1 that maintains glioblastoma cancer stem cells and shows targeting this loop reduces tumor growth.

bioRxiv · Jan 26, 2019Cancer Biology