Structural and molecular basis of cross-seeding barriers in amyloids
A. Loquet, A. Daskalov, V. Coustou, N. El Mammeri, M. Berbon, L. Andreas, B. Bardiaux, J. Stanek, A. Noubhani, B. Kauffmann, J. Wall, G. Pintacuda, S. Saupe, B. Habenstein
This study identifies molecular determinants that prevent cross-seeding between structurally similar amyloids, revealing that side-chain positions, not just backbone structure, dictate prion specificity.
bioRxiv · Jul 6, 2020Biochemistry