Amyloidogenic core of a human {lambda}-III immunoglobulin light chain fibril and their germline variants probed by MAS solid state NMR
T. Pradhan, K. Annamalai, R. Sarkar, S. Huhn, U. Hegenbart, S. Schoenland, M. Faendrich, B. Reif
This study uses MAS solid-state NMR to analyze the structure of amyloid fibrils from a human lambda-III immunoglobulin light chain and identifies a key mutation affecting fibril conformation.
bioRxiv · Oct 2, 2020 · PreprintBiophysics