R. Sarkar

Impact of gravitational forces on Red Blood Cell dynamics in biofluid suspension

This study uses DPD simulations to show gravity affects red blood cell shape, alignment, and interactions in biofluids, with metrics like elongation and center of mass decreasing under higher gravity.

CELL CYCLE STATE PREDICTION USING GRAPH NEURAL NETWORKS

The paper predicts mitosis stages using a CNN followed by a GNN, incorporating timestamps as a graph to model internal interactions, achieving performance comparable to state-of-the-art methods.

Glucocorticoid signaling mediates CD8+ T cell memory differentiation

The paper shows glucocorticoids enhance CD8+ T cell memory differentiation by promoting tissue-homing TRM cells and metabolic shifts via AMPK and STAT3/5 signaling.

Correlation in Domain Fluctuations Navigates Target Search of a Viral Peptide along RNA

The paper uses simulations and machine learning to show how anti-correlated RNA domain fluctuations guide viral peptide binding along RNA.

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera

The paper assesses the neutralizing activity of BNT162b2 vaccine-induced sera against SARS-CoV-2 B.1.1.7 pseudoviruses and finds equivalent neutralizing titers compared to the Wuhan strain.

Targeting conserved viral virulence determinants by single domain antibodies to block SARS-CoV2 infectivity

This study identifies single domain antibodies that neutralize SARS-CoV2 by targeting the cleavage site and receptor binding domain of the spike protein, showing their stability and effectiveness in blocking infectivity.

Modeling PPRV pathogenesis in mice to assess the contribution of innate cells and anti-viral T cells

This study establishes a mouse model to investigate PPRV pathogenesis, showing that IFNR KO mice succumb to infection regardless of dose, with neutrophils/macrophages transporting virus to CNS and CD8+ T cells providing protection.

Amyloidogenic core of a human {lambda}-III immunoglobulin light chain fibril and their germline variants probed by MAS solid state NMR

This study uses MAS solid-state NMR to analyze the structure of amyloid fibrils from a human lambda-III immunoglobulin light chain and identifies a key mutation affecting fibril conformation.

A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets

This paper identifies a direct interaction between JEV capsid protein and non-lipidated MAP1LC3 on replication membranes and lipid droplets, independent of p62/SQSTM1.

Comprehensive analysis of genomic diversity of SARS-CoV-2 in different geographic regions of India: An endeavour to classify Indian SARS-CoV-2 strains on the basis of co-existing mutations

This study analyzes SARS-CoV-2 genomic diversity in India, identifying 33 mutations and classifying strains into 22 groups based on co-existing mutations.

Cooperation only for high rewards - a solvable task-based study on free-ranging dogs

This study investigates cooperation and social tolerance in free-ranging dogs through three tasks with varying food rewards, finding context-dependent cooperation and food sharing.