Protease Resistance of ex vivo Amyloid Fibrils implies the proteolytic Selection of disease-associated Fibril Morphologies
J. Schoenfelder, P. B. Pfeiffer, T. Pradhan, J. Bijzet, B. P. C. Hazenberg, S. O. Schoenland, U. Hegenbart, B. Reif, C. Haupt, M. Faendrich
The paper shows ex vivo amyloid fibrils are more protease stable than in vitro fibrils, supporting the proteolytic selection hypothesis for disease-associated fibril morphologies.
bioRxiv · Jul 5, 2021Biochemistry