Author

S. Sekulovski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. Trowitzsch· 2 shared A. Pitiriciu· 1 shared C. Schmidt· 1 shared E. P. Ramsay· 1 shared F. Baas· 1 shared J. Martinez· 1 shared K. Heitmeier· 1 shared L. S. Stelzl· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

S. Trowitzsch

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2 papers

Recent·Most cited

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

S. Sekulovski, L. Susac, L. S. Stelzl, R. Tampe, S. Trowitzsch

This study presents cryo-EM structures of human TSEN with pre-tRNAs, revealing substrate recognition mechanisms and structural basis of PCH-associated mutations.

bioRxiv · Sep 3, 2022Biochemistry

Assembly defects of the human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

S. Sekulovski, P. Devant, S. Panizza, T. Gogakos, A. Pitiriciu, K. Heitmeier, E. P. Ramsay, M. Barth, C. Schmidt, S. Weitzer, T. Tuschl, F. Baas, J. Martinez, S. Trowitzsch

This study shows that TSEN assembly defects in PCH patients impair pre-tRNA processing by reducing cleavage activity despite normal endonuclease activity.

bioRxiv · Aug 3, 2020Biochemistry