J. Martinez

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning

The paper uses machine learning to analyze spatial lipidomic changes in mouse lungs exposed to allergens and ozone, revealing sex-specific lipid distribution differences.

A Mimicry-Based Strategy Between Human and Commensal Antigens for the Development of a New Family of Immune Therapies for Cancer

This paper introduces OncoMimics, a peptide-based immunotherapy using molecular mimicry between commensal bacterial and tumor antigens to induce cross-reactive T cell responses, showing early clinical success in glioblastoma.

Rapid evolution of Wolbachia genomes in mosquito cell culture

This study tracks short-term Wolbachia genome evolution in mosquito cell culture, identifying mutations linked to bacterial density changes and signs of selective evolution.

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.

This study shows that expressing cifA and cifB genes from Wolbachia strain wAlbB in Aedes aegypti testes induces CI-like sterility, which can be rescued by maternal cifA expression.

Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates

This study uses cryo-electron tomography to reveal that PRC1-CBX8 condensates are porous and dynamic, challenging the notion of rigid chromatin compaction in gene repression.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1

The paper identifies how PYROXD1 protects the tRNA ligase complex from oxidative stress through structural and functional interactions.

Metabolic Signatures of Performance in Elite World Tour Professional Cyclists

This study identifies metabolic signatures in elite cyclists during training and competition, revealing differences in metabolite profiles between exercise modes and race stages.

Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana

This study characterizes the structural and functional properties of two multimodular triphosphosphate tunnel metalloenzymes in Arabidopsis thaliana, revealing their roles in developmental transitions.

Synthetic Multiantigen MVA Vaccine COH04S1 Protects Against SARS-CoV-2 in Syrian Hamsters and Non-Human Primates

This paper shows that the synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates through various vaccination routes and dose regimens.

Wolbachia strain wAu differs in cellular perturbation and virus inhibition profiles from previously characterised Wolbachia strains

This study compares the cellular perturbation and antiviral profiles of Wolbachia strain wAu with other strains, finding unique features in its virus inhibition mechanisms.

Molecular architecture of the human tRNA ligase complex

This study presents biochemical and structural analysis of the human tRNA ligase complex, revealing its molecular architecture and catalytic mechanism.

A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

Cerebrospinal fluid (CSF) boosts metabolism and virulence expression factors in Acinetobacter baumannii

This study shows that cerebrospinal fluid (CSF) enhances virulence factor expression and metabolic processes in low-virulence Acinetobacter baumannii strains.

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen

The paper evaluates a new malaria transmission-blocking vaccine antigen, UF6b, showing it induces potent antibodies against a key epitope and is immunogenic in mice.

Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

Assembly defects of the human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

This study shows that TSEN assembly defects in PCH patients impair pre-tRNA processing by reducing cleavage activity despite normal endonuclease activity.

Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

This study identifies Irgm proteins as negative regulators of caspase-4 activation in response to LPS, showing their role in preventing septic shock.

Non-canonical autophagy in dendritic cells restricts cross-presentation and anti-tumor immunity

This study shows that Rubicon deficiency in dendritic cells enhances cross-presentation and anti-tumor immunity by increasing phagosome-to-cytosol escape and antigen degradation.

β-blockers augment L-type Ca2+ channel activity by target-selective spatially restricted β2AR-cAMP-PKA signaling in neurons

This study shows β-blockers like carvedilol can activate β2AR at low concentrations, enhancing L-type Ca2+ channel activity in neurons through localized cAMP/PKA signaling.

Addressing multiple sources of uncertainty in the estimation of parrot abundance from roost counts: a case study with the Vinaceous-breasted Parrot (Amazona vinacea)

The paper improves abundance estimates for Vinaceous-breasted Parrots by addressing detection and sampling uncertainties using roost counts and statistical models.

Divergence in the face of gene flow in two Charadrius plovers along the Chinese coast

This study examines genetic, phenotypic, and ecological divergence between two parapatric plover species along the Chinese coast, finding symmetric gene flow and evidence of ecological niche differentiation despite gene flow.