Diverse functions of closely homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence.
P. Vedula, S. Kurosaka, N. Leu, Y. Wolf, S. Shabalina, J. Wang, S. Sterling, D. Dong, A. Kashina
The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.
bioRxiv · Dec 1, 2017Cell Biology