Amantadine disrupts lysosomal gene expression; potential therapy for COVID19
S. Smieszek, B. Przychodzen, M. H. Polymeropoulos
This study identifies amantadine as a compound that downregulates CTSL/CTSB gene expression and disrupts the lysosomal pathway, potentially inhibiting SARS-CoV-2 replication.
bioRxiv · Apr 5, 2020 · PreprintMicrobiology