Author

M. H. Polymeropoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Organism:zebrafish· 1

Frequent Co-Authors

G. Birznieks· 2 shared S. P. Smieszek· 2 shared A. J. Zimmerman· 1 shared B. Keenan· 1 shared B. P. Przychodzen· 1 shared B. Przychodzen· 1 shared B. S. Prabhakar· 1 shared C. M. Polymeropoulos· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

G. Birznieks

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish

F. Doldur Balli, S. P. Smieszek, B. Keenan, A. J. Zimmerman, O. J. Veatch, C. M. Polymeropoulos, G. Birznieks, M. H. Polymeropoulos

This study tests three HCN channel blockers on zebrafish sleep/wake behavior, finding dose-dependent effects on sleep latency, activity, and nighttime sleep.

bioRxiv · May 5, 2023Pharmacology & Toxicology

Dual Inhibition of Cathepsin L and 3CL-Pro by GC-376 Constrains SARS Cov2 Infection Including Omicron Variant

B. S. Prabhakar, P. Kumar, K. Ratia, J. M. Richner, G. R. J. Thatcher, R. Kadam, S. P. Smieszek, B. P. Przychodzen, V. Koprivica, G. Birznieks, M. H. Polymeropoulos

This study shows that dual inhibition of cathepsin-L and 3CL-Pro by GC-376 effectively inhibits SARS-CoV-2 infection, including the Omicron variant, in highly susceptible cell lines.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Amantadine disrupts lysosomal gene expression; potential therapy for COVID19

S. Smieszek, B. Przychodzen, M. H. Polymeropoulos

This study identifies amantadine as a compound that downregulates CTSL/CTSB gene expression and disrupts the lysosomal pathway, potentially inhibiting SARS-CoV-2 replication.

bioRxiv · Apr 5, 2020 · PreprintMicrobiology