Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture
P. K. Singh, E. N. Simoes-Pires, Z.-L. Chen, D. Torrente, M. Calvano, A. Sharma, S. Strickland, E. H. Norris
This study shows lecanemab blocks Aβ/fibrinogen complex formation, reducing clot abnormalities and synaptotoxicity in AD models.
Proceedings of the National Academy of Sciences · Apr 15, 2024Peer-reviewedBiochemistry