The ratio of cytotoxic lymphocytes to M2-like macrophages is prognostic in immunogenic tumors
A. Mezheyeuski, M. Backman, J. Mattsson, A. Martin-Bernabe, C. Larsson, I. Hrynchyk, K. Hammarström, S. Ström, J. Ekström, S. Mauchanski, S. Khelashvili, M. Agnarsdottir, P.-H. Edqvist, J. Huvila, U. Segersten, , T. Sjöblom
The paper identifies a prognostic signature based on the ratio of cytotoxic lymphocytes to M2-like macrophages in tumor microenvironments, showing better survival prediction than existing immune scores in colon cancer and other high-mutation burden cancers.
bioRxiv · Mar 24, 2021 · PreprintCancer Biology