Author

C. Larsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Holmberg· 2 shared P. Bullova· 2 shared P. Kogner· 2 shared S. Schlisio· 2 shared A. Borg· 1 shared A. Ehinger· 1 shared A. M. George· 1 shared A. Martin-Bernabe· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

J. Holmberg

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4 papers

Recent·Most cited

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors.

O. C. Bedoya-Reina, W. Li, M. Arceo, M. Plescher, P. Bullova, H. Pui, M. Kaucka, P. Kharchenko, T. Martinsson, J. Holmberg, I. Adameyko, Q. Deng, C. Larsson, C. Juhlin, P. Kogner, S. Schlisio

The paper identifies distinct cellular identities in low and high-risk neuroblastoma tumors using single-nuclei transcriptomes, linking them to clinical outcomes and age at diagnosis.

bioRxiv · Mar 26, 2021Cancer Biology

The ratio of cytotoxic lymphocytes to M2-like macrophages is prognostic in immunogenic tumors

A. Mezheyeuski, M. Backman, J. Mattsson, A. Martin-Bernabe, C. Larsson, I. Hrynchyk, K. Hammarström, S. Ström, J. Ekström, S. Mauchanski, S. Khelashvili, M. Agnarsdottir, P.-H. Edqvist, J. Huvila, U. Segersten, , T. Sjöblom

The paper identifies a prognostic signature based on the ratio of cytotoxic lymphocytes to M2-like macrophages in tumor microenvironments, showing better survival prediction than existing immune scores in colon cancer and other high-mutation burden cancers.

bioRxiv · Mar 24, 2021 · PreprintCancer Biology

Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors

Y. Shi, V. Rraklli, E. Maxymovitz, S. Li, I. Westerlund, O. B. Reina, J. Yuan, P. Bullova, C. C. Juhlin, A. Stenman, C. Larsson, P. Kogner, M. J. O'Sullivan, S. Schlisio, J. Holmberg

This study identifies splicing-dependent RNA-fusions in neuroblastoma and shows spliceosome inhibition reduces tumor growth.

bioRxiv · Jan 31, 2020 · PreprintCancer Biology

The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome

C. Brueffer, S. Gladchuk, C. Winter, J. Vallon-Christersson, C. Hegardt, J. Häkkinen, A. M. George, Y. Chen, A. Ehinger, C. Larsson, N. Loman, M. Malmberg, L. Ryden, A. Borg, L. H. Saal

The paper develops a pipeline to detect mutations from RNA-seq data in breast cancer and shows it can identify mutations in key genes and pathways in 86.8% of tumors.

bioRxiv · Jan 30, 2020Cancer Biology