bioRxivCancer BiologyPreprint
The ratio of cytotoxic lymphocytes to M2-like macrophages is prognostic in immunogenic tumors
A. Mezheyeuski, M. Backman, J. Mattsson, A. Martin-Bernabe, C. Larsson, I. Hrynchyk, K. Hammarström, S. Ström, J. Ekström, S. Mauchanski, S. Khelashvili, M. Agnarsdottir, P.-H. Edqvist, J. Huvila, U. Segersten, P.-U. Malmström, J. Botling, B. Nodin, C. Hedner, D. Borg, J. Bärndstedt, H. Sartor, K. Leandersson, B. Glimelius, A. Portyanko, , T. Sjöblom
Abstract
Immune cells in the microenvironment shape tumor development and progression. The prognostic value of T-cell-based immune scores exceeds those of clinical parameters in colon cancer, but reflects only a part of the anti-tumor immune response. Here, we assessed 15 distinct immune cell classes and identified a simple prognostic signature based on pro- and anti-tumoral immune cells in the tumor microenvironment. The ratio of cytotoxic lymphocytes to tumor supportive macrophages predicted survival better than the state-of-art immune score in colon cancer and had the highest relative contribution to survival prediction when compared to established clinical parameters. This signature was prognostic also in other cancers with high mutation burden, such as those of the lung, bladder, esophagus, and melanomas, supporting broad clinical applicability. One Sentence SummaryThe CD8/M2 ratio in tumor tissue defines prognosis in immunogenic cancers
- organism: human
- assay: bulk RNA-seq
- research focus: protein folding & dynamics
- research focus: cell type annotation
- research focus: differential expression
- research focus: gene regulatory network inference
- approach: statistical model
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Context-dependent effects explain divergent prognostic roles of Tregs in cancer
E. Amblard, V. Soumelis·bioRxiv·May 2, 2022
- The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome
M. Foroutan, R. Molania, … N. D. Huntington·bioRxiv·Dec 19, 2020
- The Primary Tumor Immune Microenviornment Status Predicts the Response to Immunotherapy and Overall Survival in Breast Cancer
A. K. Moorthy, A. Quinn·bioRxiv·Jul 3, 2020
- Tertiary lymphoid structures are associated with enhanced macrophage activation, immune checkpoint expression and predict outcome in cervical cancer.
L. Gorvel, M. Panouillot, … D. Olive·bioRxiv·Aug 17, 2023
- The Prognostic Value of Tumor-Infiltrating Immune Cells in Gynecologic Cancers
- Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients
M. Azimi, S. Cho, … J. H. M. Prehn·bioRxiv·Jan 30, 2024