Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosome
W. Li, S. T.- L. Chang, F. R. Ward, J. H. D. Cate
The paper shows PF846 inhibits translation by trapping nascent chains on the ribosome, revealing a new mechanism for targeting protein synthesis.
bioRxiv · May 20, 2020 · PreprintBiophysics