Author

F. R. Ward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:protein structure· 1

Frequent Co-Authors

J. H. D. Cate· 3 shared A. Schepartz· 2 shared O. Ad· 2 shared W. Li· 2 shared Z. L. Watson· 2 shared E. Montabana· 1 shared J. Banfield· 1 shared J. Cate· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

J. H. D. Cate

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Author profile →

4 papers

Recent·Most cited

Structure of the Bacterial Ribosome at 2 A Resolution

Z. L. Watson, F. R. Ward, R. Meheust, O. Ad, A. Schepartz, J. Banfield, J. H. D. Cate

This paper presents a 2.0 Å resolution model of the E. coli 70S ribosome using cryo-EM, revealing detailed chemical interactions, modifications, and solvation.

bioRxiv · Jun 26, 2020Biophysics

Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosome

W. Li, S. T.- L. Chang, F. R. Ward, J. H. D. Cate

The paper shows PF846 inhibits translation by trapping nascent chains on the ribosome, revealing a new mechanism for targeting protein synthesis.

bioRxiv · May 20, 2020 · PreprintBiophysics

Defects in the assembly of ribosomes selected for β-amino acid incorporation

F. R. Ward, Z. L. Watson, O. Ad, A. Schepartz, J. H. D. Cate

This study investigates a mutant ribosome, P7A7, evolved for β-amino acid incorporation, revealing defects in its assembly that reduce in vitro activity.

bioRxiv · Aug 13, 2019Biochemistry

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

W. Li, F. R. Ward, K. McClure, S. T. Chang, E. Montabana, S. Liras, R. Dullea, J. Cate

This study identifies how PF-846 selectively stalls ribosome translation by binding in a specific pocket and altering nascent chain path, revealing a mechanism for targeted protein inhibition.

bioRxiv · Jan 9, 2019Biophysics