Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis
I. Ninou, I. Sevastou, C. Magkrioti, E. Kaffe, G. Stamatakis, S. Thivaios, G. Panayotou, J. Aoki, G. Kollias, V. Aidinis
The paper shows that deleting Autotaxin in CD11b+ cells reduces experimental autoimmune encephalomyelitis severity, indicating a pathogenic role for the ATX/LPA axis in neuroinflammation.
bioRxiv · Nov 20, 2019Immunology