G. Kollias

A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus

This paper creates a human IL-23A overexpressing mouse model of SLE and shows it develops autoimmune features similar to human SLE.

Cellular complexity and crosstalk in murine TNF-dependent ileitis: Different fibroblast subsets propel spatially defined ileal inflammation through TNFR1 signalling

This study identifies fibroblast subsets in murine TNF-dependent ileitis that drive inflammation through TNFR1 signaling in distinct intestinal layers.

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis

This study identifies dysregulation of γδ intraepithelial lymphocytes (IELs) before the onset of Crohn's disease-like ileitis in a mouse model.

Upregulation of CD55 complement regulator in distinct PBMC subpopulations of COVID-19 patients is associated with suppression of interferon responses.

The paper identifies upregulated CD55 in PBMC subpopulations of severe COVID-19 patients, linked to reduced interferon responses.

Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.

This study identifies Amisulpride as a potential therapeutic for arthritis by reducing synovial fibroblast activation, independent of its known targets.

Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis

This study profiles single-cell transcriptomes and chromatin accessibility of synovial fibroblasts in TNF-driven arthritis, identifying disease-specific subtypes and key regulatory factors.

miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis

This study shows miR-221/222 promotes synovial fibroblast expansion and worsens TNF-mediated arthritis by regulating cell cycle and ECM pathways.

Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis

The paper identifies and characterizes Col6a1+/CD201+ mesenchymal cells in the intestine, showing their role in morphogenesis, homeostasis, and plasticity during inflammation.

Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis

This paper characterizes a transmembrane TNF-driven mouse model of spondyloarthritis, showing ectopic bone formation, systemic bone loss, and comorbid heart valve pathology, with early anti-TNF treatment reducing inflammation.

Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis

The paper shows that deleting Autotaxin in CD11b+ cells reduces experimental autoimmune encephalomyelitis severity, indicating a pathogenic role for the ATX/LPA axis in neuroinflammation.