Author

S. Thiyagarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:statistical model· 2 Approach:biophysical modeling· 1 Organism:fungi (other)· 1 Approach:mechanistic / dynamical model· 1 Approach:simulation· 1 Organism:yeast· 1

Frequent Co-Authors

B. O'Shaughnessy· 5 shared S. Wang· 3 shared Z. A. McDargh· 3 shared E. Karatekin· 2 shared B. E. Alcott· 1 shared D. An· 1 shared E. Antipov· 1 shared H. F. Chin· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCell Biology

B. O'Shaughnessy

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Author profile →

5 papers

Recent·Most cited

Contractile ring constriction and septation in fission yeast are integrated mutually stabilizing processes

S. Thiyagarajan, Z. A. McDargh, S. Wang, B. O'Shaughnessy

This study models the integrated contractile ring and septation system in fission yeast, showing mutual stabilization between the two processes.

bioRxiv · Jun 25, 2021 · PreprintCell Biology

Myosins generate contractile force and maintain organization in the cytokinetic contractile ring

Z. A. McDargh, S. Wang, H. F. Chin, S. Thiyagarajan, E. Karatekin, T. D. Pollard, B. O'Shaughnessy

This study measures contractile ring tension in fission yeast and identifies Myo2 and Myp2 as key contributors to force generation and ring organization.

bioRxiv · May 2, 2021 · PreprintCell Biology

Myosin turnover controls actomyosin contractile instability

S. Thiyagarajan, S. Wang, T. G. Chew, J. Huang, M. BALASUBRAMANIAN, B. O'Shaughnessy

The paper observes actomyosin contractile instability in isolated cytokinetic rings and shows myosin II turnover prevents catastrophic aggregation and fracture.

bioRxiv · Mar 18, 2021Cell Biology

The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

Z. Wu, N. Dharan, Z. A. McDargh, S. Thiyagarajan, B. O'Shaughnessy, E. Karatekin

This study shows Synaptotagmin-1 promotes fusion pore dilation by reorienting SNARE complexes through calcium-induced C2 domain insertion, enhancing neurotransmitter and hormone release.

bioRxiv · Mar 8, 2021Biophysics

Membrane pore energetics and the pathways to membrane rupture

D. An, S. Thiyagarajan, E. Antipov, B. E. Alcott, B. O'Shaughnessy

This study uses simulations to show that membrane rupture occurs through different pathways depending on tension, without requiring long-lived metastable pore states.

bioRxiv · Jun 29, 2020 · PreprintBiophysics