Phage T3 overcomes the BREX defence through SAM cleavage and inhibition of SAM synthesis
A. Andriianov, S. Triguis, A. Drobiazko, N. Sierro, N. V. Ivanov, M. Selmer, K. Severinov, A. Isaev
This study shows that bacteriophage T3 evades BREX defence by degrading SAM and inhibiting its synthesis, revealing SAM's role as a co-factor in phage defence systems.
bioRxiv · Feb 27, 2023 · PreprintMicrobiology