Author

M. Selmer

Primary ORCID profile (0000-0001-9079-2774 · 7 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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M. SelmeriD7 papers · Uppsala University

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

S. Kanchugal P· 2 shared A. Andriianov· 1 shared A. Drobiazko· 1 shared A. Gogoll· 1 shared A. Isaev· 1 shared A. Söderholm· 1 shared D. Andersson· 1 shared G. V. Isaksen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

S. Kanchugal P

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3 papers

Recent·Most cited

Phage T3 overcomes the BREX defence through SAM cleavage and inhibition of SAM synthesis

A. Andriianov, S. Triguis, A. Drobiazko, N. Sierro, N. V. Ivanov, M. Selmer, K. Severinov, A. Isaev

This study shows that bacteriophage T3 evades BREX defence by degrading SAM and inhibiting its synthesis, revealing SAM's role as a co-factor in phage defence systems.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

X. Guo, A. Söderholm, S. Kanchugal P, G. V. Isaksen, O. Warsi, U. Eckhard, S. Trigüis, A. Gogoll, J. Jerlström-Hultqvist, J. Aqvist, D. Andersson, M. Selmer

The paper reveals the structure and mechanism of phage-encoded SAM lyases, showing they function as lyases rather than hydrolases, forming MTA and L-homoserine lactone through a unimolecular reaction.

bioRxiv · Aug 16, 2020Biochemistry

Structural recognition of spectinomycin by resistance enzyme ANT(9) from Enterococcus faecalis

S. Kanchugal P, M. Selmer

This study presents the first structures of spectinomycin bound to the ANT(9) enzyme, revealing its binding mechanism and specificity compared to streptomycin.

bioRxiv · Mar 23, 2020Biochemistry