Author

S. V. Lindskrog

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Research Focus:clustering· 2 Assay:proteomics· 2

Frequent Co-Authors

L. Dyrskjot· 5 shared J. B. Jensen· 3 shared M. Knudsen· 3 shared P. Lamy· 3 shared T. Strandgaard· 3 shared F. Prip· 2 shared I. Nordentoft· 2 shared S. S. Schmokel· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCancer Biology

L. Dyrskjot

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Author profile →

5 papers

Recent·Most cited

Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancer

T. Strandgaard, I. Nordentoft, K. Birkenkamp-Demtroder, L. Salminen, F. Prip, J. Rasmussen, T. G. Andreasen, S. V. Lindskrog, E. Christensen, P. Lamy, M. Knudsen, T. Steiniche, J. B. Jensen, L. Dyrskjot

This study shows that field cancerization in bladder cancer is linked to worse outcomes, higher mutational burden, and T-cell exhaustion, with urinary tumor DNA levels reflecting disease status.

bioRxiv · Feb 20, 2023 · PreprintCancer Biology

Single nucleus and spatially resolved intra-tumor subtype heterogeneity in bladder cancer

S. V. Lindskrog, S. S. Schmokel, I. Nordentoft, P. Lamy, M. Knudsen, F. Prip, T. Strandgaard, J. B. Jensen, L. Dyrskjot

This study investigates intra-tumor subtype heterogeneity in bladder cancer using single nucleus RNA-sequencing and spatial transcriptomics, showing higher class 2a weight in bulk RNA-sequencing correlates with worse outcomes.

bioRxiv · Oct 27, 2022Cancer Biology

Improved Protocol for Single-Nucleus RNA-sequencing of Frozen Human Bladder Tumor Biopsies

S. S. Schmokel, I. K. Nordentoft, S. V. Lindskrog, P. Lamy, M. Knudsen, J. B. Jensen, L. Dyrskjot

This paper develops a protocol for snRNA-seq of frozen human bladder tumor biopsies, showing optimal conditions for nuclei isolation with minimal transcriptomic changes.

bioRxiv · Oct 14, 2022Cancer Biology

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

D. Ranti, Y.-S. Wang, J. Daza, C. Bieber, B. Salome, E. Merritt, J.-A. Cavallo, E. Hegewisch-Solloa, E. M. Mace, A. M. Farkas, S. Schroff, B. Lee, M. Tran, T. Strandgaard, S. V. Lindskrog, , A. Horowitz

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

bioRxiv · Mar 6, 2022 · PreprintImmunology

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

M. Shi, A. Moreno-Vega, J. Fontugne, X.-Y. Meng, F. Dufour, A. Kamoun, S. V. Lindskrog, A. Rapinat, C. Dunois-Larde, M.-L. Lapage, E. Chapeaublanc, O. Levrel, T. Lebret, A. Almeida, A. De Reynies, , I. BERNARD-PIERROT

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

bioRxiv · Sep 2, 2021 · PreprintCancer Biology