L. Dyrskjot

Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancer

This study shows that field cancerization in bladder cancer is linked to worse outcomes, higher mutational burden, and T-cell exhaustion, with urinary tumor DNA levels reflecting disease status.

Single nucleus and spatially resolved intra-tumor subtype heterogeneity in bladder cancer

This study investigates intra-tumor subtype heterogeneity in bladder cancer using single nucleus RNA-sequencing and spatial transcriptomics, showing higher class 2a weight in bulk RNA-sequencing correlates with worse outcomes.

Improved Protocol for Single-Nucleus RNA-sequencing of Frozen Human Bladder Tumor Biopsies

This paper develops a protocol for snRNA-seq of frozen human bladder tumor biopsies, showing optimal conditions for nuclei isolation with minimal transcriptomic changes.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

Mutational analysis of field cancerization in bladder cancer

The paper analyzes mutations in normal and tumor bladder tissues to study field cancerization, finding more mutations in normal tissue from multifocal disease patients and non-tumor-specific driver mutations.

A consensus molecular classification of muscle-invasive bladder cancer

The paper identifies six consensus molecular classes of muscle-invasive bladder cancer using transcriptomic data and classification systems, providing a framework for future biomarker validation.