A. De Reynies

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

The paper develops patient-derived xenografts (PDXs) for bladder and ureteral cancers, identifies molecular subtypes, and shows that combined FGFR/EGFR inhibition is more effective than single-agent therapy for FGFR3-mutant tumors.

FGFR3 activating mutations induce luminal-like papillary bladder tumor formation and favor a male gender bias.

This study shows FGFR3-S249C mutations drive luminal-like papillary bladder tumors in mice and correlate with male gender bias and AR activity in human tumors.

webMCP-counter: a web interface for transcriptomics-based quantification of immune and stromal cells in heterogeneous human or murine samples

webMCP-counter provides a web interface for using MCP-counter and mMCP-counter methods to estimate immune and stromal cell composition in bulk transcriptomic data from human or murine samples.

The PAXFOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

This study shows PAXFOXO1 fusion proteins drive neural cells to become ARMS-like cells but are limited by G1 cell cycle arrest, which can be overcome by CYCLIN D1 or MYCN.

PPARG is a tumor suppressor in basal bladder tumors offering new potential therapeutic opportunities.

The paper identifies PPARγ as a tumor suppressor in basal bladder tumors and suggests therapeutic opportunities through PPARγ activation.

Large-scale pan-cancer analysis reveals broad prognostic association between TGF-β ligands, not Hedgehog, and GLI1/2 expression in tumors

The paper analyzes GLI1/2 expression across multiple cancers and finds that TGF-β ligands, not Hedgehog, are prognostically associated with GLI1/2 expression.

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

The paper investigates the context-dependent oncogenic effects of the GATA3 X308_Splice mutation in breast cancer, showing its differential impact based on hormonal status.

A consensus molecular classification of muscle-invasive bladder cancer

The paper identifies six consensus molecular classes of muscle-invasive bladder cancer using transcriptomic data and classification systems, providing a framework for future biomarker validation.

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

The paper assesses the relationship between cancer stemness and immune response across 21 solid cancers, finding negative associations between stemness and anticancer immunity.