Werner syndrome helicase is a selective vulnerability of microsatellite instability high tumor cells
S. Lieb, S. Blaha-Ostermann, E. Kamper, K. Ehrenhoefer-Woelfer, A. Schlattl, A. Wernitznig, J. J. Lipp, K. Nagasaka, G. Bader, R. A. Neumueller, N. Kraut, M. A. Pearson, M. Petronczki, S. Woehrle
This study identifies Werner syndrome helicase (WRN) as a selective vulnerability in microsatellite instability-high (MSI-H) cancer cells, showing that its inactivation impairs viability and causes genomic instability.
bioRxiv · Jan 26, 2019Cancer Biology