K. Nagasaka

Cohesin supercoils DNA during loop extrusion

This study shows cohesin supercoils DNA during loop extrusion, influencing genome architecture through both looping and supercoiling.

Injectable microcapillary network hydrogels engineered by liquid-liquid phase separation for stem cell transplantation

This paper develops injectable hydrogels with microcapillary networks to improve stem cell transplantation by enhancing tissue integration and graft survival.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

Hotmelt tissue adhesive with supramolecularly-controlled sol-gel transition for preventing postoperative abdominal adhesion

This paper develops a hotmelt tissue adhesive that prevents postoperative abdominal adhesions by controlling sol-gel transitions through supramolecular hydrogen bonding.

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

Absolute quantification of cohesin, CTCF and their regulators in human cells

The paper measures absolute copy numbers and dynamics of cohesin, CTCF, and related proteins in human cells, revealing that some genomic enrichment sites are unoccupied in single cells.

Werner syndrome helicase is a selective vulnerability of microsatellite instability high tumor cells

This study identifies Werner syndrome helicase (WRN) as a selective vulnerability in microsatellite instability-high (MSI-H) cancer cells, showing that its inactivation impairs viability and causes genomic instability.