The BAF A12T mutation associated with premature aging impedes lamin A/C recruitment to sites of nuclear rupture, contributing to nuclear envelope fragility.
A. F. J. Janssen, A. Marcelot, S. Y. Breusegem, P. Legrand, S. Zinn-Justin, D. Larrieu
This study shows the BAF A12T mutation impairs lamin A/C recruitment to nuclear ruptures, causing nuclear fragility in NGPS patient cells.
bioRxiv · Feb 25, 2022Cell Biology