Author

P. Legrand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Zinn-Justin· 3 shared A. N. Zelensky· 2 shared D. Ristic· 2 shared R. Guerois· 2 shared R. Kanaar· 2 shared S. E. van Rossum-Fikkert· 2 shared S. Miron· 2 shared V. Ropars· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

S. Zinn-Justin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Arf family GTPases are present in Asgard archaea

R. Vargova, R. Chevreau, M. Alves, C. Courbin, K. Terry, P. Legrand, M. Elias, J. Menetrey, J. B. Dacks, C. L. Jackson

This study identifies ArfR GTPases in Asgard archaea, showing they are ancestral to eukaryotic Arf family proteins and suggest early evolution of endomembrane systems.

bioRxiv · Feb 28, 2024 · PreprintEvolutionary Biology

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces

S. Miron, P. Legrand, S. E. van Rossum-Fikkert, D. Ristic, A. Badar, R. Kanaar, S. Zinn-Justin, A. N. Zelensky

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

bioRxiv · Oct 5, 2023Biochemistry

Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe

F. Ouasti, M. Audin, K. Freon, J.-P. Quivy, M. Tachekort, E. Cesard, A. Thureau, V. Ropars, P. F. Varela, G. Moal, I. Soumana-Amadou, A. Uryga, P. Legrand, J. Andreani, R. Guerois, , F. Ochsenbein

This study identifies how disordered regions and folded modules in SpCAF-1 from S. pombe enable histone deposition by mediating interactions with histones and PCNA during DNA replication.

bioRxiv · Jun 2, 2023Biochemistry

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

R. Ghouil, S. Miron, K. Sato, D. Ristic, S. E. van Rossum-Fikkert, P. Legrand, M. Ouldali, J.-M. Winter, V. Ropars, G. David, A.-A. Arteni, C. Wyman, P. Knipscheer, R. Kanaar, A. N. Zelensky, S. Zinn-Justin

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

bioRxiv · Apr 27, 2023Biochemistry

DNA-binding mechanism and evolution of Replication Protein A

C. Madru, M. Martinez-Carranza, S. Laurent, A. C. Alberti, M. Chevreuil, B. Raynal, A. Haouz, R. A. Le Meur, M. Delarue, D. Flament, M. Krupovic, P. Legrand, L. Sauguet

This study characterizes the DNA-binding mechanism of RPA from Pyrococcus abyssi using crystal and cryo-EM structures, revealing conserved features and a novel archaeal-specific domain.

bioRxiv · Jul 20, 2022Biochemistry

The BAF A12T mutation associated with premature aging impedes lamin A/C recruitment to sites of nuclear rupture, contributing to nuclear envelope fragility.

A. F. J. Janssen, A. Marcelot, S. Y. Breusegem, P. Legrand, S. Zinn-Justin, D. Larrieu

This study shows the BAF A12T mutation impairs lamin A/C recruitment to nuclear ruptures, causing nuclear fragility in NGPS patient cells.

bioRxiv · Feb 25, 2022Cell Biology

ComF is a key mediator in single-stranded DNA transport and handling during natural transformation

P. P. Damke, L. Celma, S. Kondekar, A. M. Di Guilmi, S. Marsin, J. Depagne, X. Veaute, P. Legrand, H. Walbott, J. Vercruyssen, R. Guerois, S. Quevillon-Cheruel, J. P. Radicella

This study identifies ComF as essential for DNA transport and handling during natural transformation in bacteria, revealing its structural features and functional role in DNA processing.

bioRxiv · Aug 4, 2021Microbiology

Trypanosoma brucei ultra-structure cell modifications caused by knockdown of the ribonuclease Rrp44/Dis3

G. Cesaro, P. M. Hiraiwa, F. R. G. Carneiro, V. Rouam, P. Legrand, J. J. Conesa, M. Refregiers, E. Pereiro, B. G. Guimaraes, F. Jamme, N. I. T. Zanchin

This study shows that TbRRP44 depletion in Trypanosoma brucei causes vacuole expansion, nuclear enlargement, mitochondrial inactivation, and autophagy, leading to cell death.

bioRxiv · Feb 29, 2020 · PreprintCell Biology