Author

S. Y. Shvartsman

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Evolutionary Biology· 1

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Organism:Drosophila· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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E. P. Andrianova· 1 shared I. B. Zhulin· 1 shared R. A. Marmion· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperEvolutionary Biology

E. P. Andrianova

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1 paper

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Evolutionary BiologybioRxivPreprintMar 9, 2023

Evolutionary history of MEK1 illuminates the nature of cancer and RASopathy mutations

E. P. Andrianova, R. A. Marmion, S. Y. Shvartsman, I. B. Zhulin

The paper constructs an evolutionary history of MEK1 to distinguish disease-causing from benign mutations, showing that intolerant variants are damaging in Drosophila.

DOI 10.1101/2023.03.09.531944

Drosophilastatistical model

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