I. B. Zhulin

FlhE functions as a chaperone to prevent formation of periplasmic flagella in Gram-negative bacteria

The paper identifies FlhE as a periplasmic chaperone that prevents the formation of periplasmic flagella in Salmonella, which disrupts cell wall synthesis and causes cell lysis.

Diverse domain architectures of CheA histidine kinase, a central component of bacterial and archaeal chemosensory systems

The paper conducts a genomic survey of CheA domain composition across bacteria and archaea, identifying core domains and common deviations in domain architecture.

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor

The paper investigates the origin and functional diversity of PAS domains across species, identifying their bacterial origin and functional adaptations in different lineages.

Amine recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor

The paper identifies a sequence motif specific for amine-sensing domains in bacterial and archaeal receptors, showing their evolution from a universal amino acid sensor and enabling functional studies of regulatory systems.

Evolutionary history of MEK1 illuminates the nature of cancer and RASopathy mutations

The paper constructs an evolutionary history of MEK1 to distinguish disease-causing from benign mutations, showing that intolerant variants are damaging in Drosophila.

Amino acid sensor conserved from bacteria to humans

The paper identifies a conserved amino acid recognition motif in dCache_1 domains across species, showing it binds amino acids in bacteria and human calcium channels involved in pain and neurodevelopmental disorders.

Interdimer zipping in the chemoreceptor signaling domain revealed by molecular dynamics simulations

This study uses molecular dynamics simulations to reveal interdimer interactions in the Tsr chemoreceptor signaling domain, showing hydrophobic and electrostatic forces stabilize the trimer-of-dimers structure.