Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects
Y. Lin, S. Z. Grinter, Z. Lu, X. Xu, H. Z. Wang, H. Liang, P. Hou, J. Gao, C. Clausen, J. Shi, W. Zhao, Z. Ma, Y. Liu, K. M. White, L. Zhao, , J. Cui
This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.
bioRxiv · Feb 25, 2021Biophysics