K. M. White

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

This study evaluates the antiviral activity of nirmatrelvir, molnupiravir, and remdesivir against the SARS-CoV-2 Omicron variant and confirms their potency.

Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

This paper evaluates the antiviral activity of Nirmatrelvir against multiple SARS-CoV-2 variants using qRT-PCR in VeroE6 cells, showing potent inhibition across all tested variants.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

Passenger mutations confound phenotypes of SARM1-deficient mice

This study shows that phenotypes in SARM1-deficient mice may be due to genetic differences between B6 and 129 backgrounds rather than SARM1 itself.

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling

This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.