Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state.
A. Padavannil, A. Murari, S.-K. Rhooms, E. Owusu-Ansah, J. A. Letts
This study reports the structure of Drosophila melanogaster complex I, revealing a helix-locked open state and explaining why it does not deactivate, with implications for pesticide and disease development.
bioRxiv · Nov 1, 2022 · PreprintBiochemistry