Author

E. Owusu-Ansah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Murari· 2 shared M. Picard· 2 shared S.-K. Rhooms· 2 shared A. K. Sood· 1 shared A. Lee· 1 shared A. Padavannil· 1 shared A. Tyagi· 1 shared A. Wingo· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

A. Murari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state.

A. Padavannil, A. Murari, S.-K. Rhooms, E. Owusu-Ansah, J. A. Letts

This study reports the structure of Drosophila melanogaster complex I, revealing a helix-locked open state and explaining why it does not deactivate, with implications for pesticide and disease development.

bioRxiv · Nov 1, 2022 · PreprintBiochemistry

A Ferroptosis-mediated regulation of the biogenesis of the oxidative phosphorylation system

A. Murari, S.-k. Rhooms, K. Hossain, T. Liu, H. Li, N. S. Goparaju, C. Osei, E. Owusu-Ansah

The paper shows that elevated ROS levels impair OXPHOS assembly via ferroptosis and mitochondrial unfolded protein response.

bioRxiv · Feb 17, 2022 · PreprintCell Biology

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

C. Trumpff, E. Owusu-Ansah, H.-U. Klein, A. Lee, V. Petyuk, T. S. Wingo, A. Wingo, M. Thambisetty, L. Ferrucci, N. Seyfried, D. A. Bennett, P. L. De Jager, M. Picard

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

bioRxiv · Jul 19, 2021Cell Biology

Ovarian Tumor Mitochondria Exhibit Abnormal Phenotypes and Blunted Associations with Biobehavioral Factors

S. Bindra, M. A. McGill, M. K. Triplett, A. Tyagi, P. H. Thaker, L. Dahmoush, M. J. Goodheart, T. Ogden, E. Owusu-Ansah, K. Karan, S. Cole, A. K. Sood, S. K. Lutgendorf, M. Picard

The paper examines mitochondrial content and function in ovarian tumors and their associations with biobehavioral factors, finding abnormal mitochondrial phenotypes and weaker biobehavioral correlations in tumors.

bioRxiv · Feb 26, 2021Cancer Biology

The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS

M. N. Islam, G. A. Gusarova, S. R. Das, L. Li, E. Monma, M. Anjaneyulu, E. Owusu-Ansah, S. Bhattacharya, J. Bhattacharya

The paper shows that mitochondrial Ca2+ uniporter (MCU) expression in alveolar type 2 cells determines ARDS severity by affecting Ca2+ buffering capacity.

bioRxiv · Jan 18, 2021 · PreprintPhysiology