Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant
Vishakha Singh, Shweta Choudhary, Mandar Bhutkar, Sanketkumar Nehul, Sabika Ali, Jitin Singla, Pravindra Kumar, Shailly Tomar
This paper develops an in silico affinity maturation pipeline to enhance nanobody binding to the SARS-CoV-2 Omicron RBD, achieving three-fold improved affinity through computational and experimental validation.
International Journal of Biological Macromolecules · Dec 13, 2024Peer-reviewedBioengineering