Author

Vishakha Singh

Indian Institute of Technology RoorkeeORCID 0000-0001-8307-3659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Organism:virus· 1

Frequent Co-Authors

Jitin SinglaiD· 2 shared Mandar BhutkariD· 2 shared Pravindra KumariD· 2 shared Sanketkumar NehuliD· 2 shared Shailly TomariD· 2 shared Shweta ChoudharyiD· 2 shared Rajesh KumariD· 1 shared Sabika Ali· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

Jitin SinglaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioengineeringInternational Journal of Biological MacromoleculesPeer-reviewedDec 13, 2024

Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant

Vishakha Singh, Shweta Choudhary, Mandar Bhutkar…·Shailly Tomar

This paper develops an in silico affinity maturation pipeline to enhance nanobody binding to the SARS-CoV-2 Omicron RBD, achieving three-fold improved affinity through computational and experimental validation.

7 citations

protein structuredeep learning

𝕏 PostBluesky

BioengineeringBiochemical and Biophysical Research CommunicationsPeer-reviewedSep 26, 2024

Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs

Vishakha Singh, Mandar Bhutkar, Shweta Choudhary…·Shailly Tomar

This study enhances the affinity of SARS-CoV-2 neutralizing nanobodies through structure-guided mutations in CDRs, resulting in improved neutralization activity against pseudovirus.

14 citationstop 4%

virusprotein structure

𝕏 PostBluesky