Shweta Choudhary

EIDD-3525 is a broad-spectrum antiviral against alphavirus infection that targets the nsP4 RNA-dependent RNA polymerase

This study identifies EIDD-3525 as a broad-spectrum antiviral against alphaviruses that inhibits RNA replication by targeting the nsP4 polymerase.

Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replication

This study identifies a new molecular interaction between G3BP1 and SARS-CoV-2 N protein and shows small molecules disrupt this interaction, reducing viral replication.

Designing and bioengineering of CDRs with higher affinity against receptor-binding domain (RBD) of SARS-CoV-2 Omicron variant

This paper develops an in silico affinity maturation pipeline to enhance nanobody binding to the SARS-CoV-2 Omicron RBD, achieving three-fold improved affinity through computational and experimental validation.

Unveiling Mechanistic and Structural Insights of EstS1 Esterase: A Potent Broad-Spectrum Phthalate Diester Degrading Enzyme

This study characterizes the structural and mechanistic properties of EstS1 esterase, revealing its role in degrading phthalate diesters through a bi-bi ping-pong mechanism and covalent substrate binding.

Enhancing affinity of neutralizing SARS-CoV-2 nanobody through facile structure-guided mutations in CDRs

This study enhances the affinity of SARS-CoV-2 neutralizing nanobodies through structure-guided mutations in CDRs, resulting in improved neutralization activity against pseudovirus.

Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS-COV-2 targeting virus-specific enzymes

This study evaluates the antiviral and anti-inflammatory effects of triterpenoids against SARS-CoV-2 by targeting viral proteases and host immune pathways.

Revealing and evaluation of antivirals targeting multiple druggable sites of RdRp complex in SARS-CoV-2

This study identifies antivirals targeting multiple sites of SARS-CoV-2 RdRp complex through in-silico screening, SPR validation, and cell-based assays, showing potent antiviral effects.

Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model

This study identifies DUB inhibitors that target SARS-CoV-2 PLpro, inhibiting its proteolytic activity and restoring immune responses in a mouse model.

Mechanistic and thermodynamic characterization of antivirals targeting druggable pocket of SARS-CoV-2 nucleocapsid

This study identifies antivirals targeting the NTD of SARS-CoV-2 N protein using structure-based drug repurposing and shows their effectiveness in inhibiting viral replication.