Mandar Bhutkar

The paper reports the crystal structures of KFDV NS5 methyltransferase and evaluates HC and CAPE as inhibitors against the enzyme.

This study identifies herbacetin as an inhibitor of dengue virus NS5 methyltransferase, revealing its binding mechanism and potential as a scaffold for antiviral drugs.

This paper develops an in silico affinity maturation pipeline to enhance nanobody binding to the SARS-CoV-2 Omicron RBD, achieving three-fold improved affinity through computational and experimental validation.

This study enhances the affinity of SARS-CoV-2 neutralizing nanobodies through structure-guided mutations in CDRs, resulting in improved neutralization activity against pseudovirus.

This paper identifies three FDA-approved drugs as inhibitors of Chikungunya virus nsP1 methyltransferase, showing antiviral efficacy in cell-based assays.