CK1a-Mediated Two-Step Subunit Remodeling of the Circadian FRQ-FRH Complex
Carolin Schunke, Bianca Ruppert, Sabine Schultz, Axel C. R. Diernfellner, Michael Brunner
The paper reveals how CK1a-mediated phosphorylation of FRQ leads to a two-step remodeling of the FRQ-FRH complex, enabling precise circadian regulation through temporal decoding of phosphorylation states.
bioRxiv · May 13, 2025 · PreprintCell Biology