Axel C. R. Diernfellner

This study shows CK1δ activity and abundance are coordinated in a cell cycle-dependent manner, with degradation and autoinhibition playing roles in different phases.

This study investigates the role of nuclear CK1δ in PER:CRY complex dynamics and circadian period regulation, showing its impact on complex formation and nuclear clearance of PER2.

The paper reveals how CK1a-mediated phosphorylation of FRQ leads to a two-step remodeling of the FRQ-FRH complex, enabling precise circadian regulation through temporal decoding of phosphorylation states.

The paper shows that antisense RNA qrf transcription is not required for circadian clock function in Neurospora crassa, but its evening rhythm is controlled by the morning repressor CSP-1.

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

The paper models how multiple random phosphorylations in clock proteins generate delays and switches necessary for circadian oscillations.

The paper shows that MXD proteins can activate transcription of MYC-repressed genes through interaction with MIZ1 and a functional DNA binding domain, revealing reciprocal antagonism between MXD and MYC in gene regulation.