The subclonal footprint of pervasive early dissemination in pancreatic cancer
Yuanchang Fang, Michelle Chan‐Seng‐Yue, Karen Ng, Amy Xin Wei Zhang, Tuan Anh Hoang, Gun Ho Jang, Sabiq Chaudhary, Catia Gaspar, Eugenia Flores Figueroa, Daniela Bevacqua, Stephanie Ramotar, Ayelet Borgida, Shawn Hutchinson, Anna Dodd, Ayah Elqaderi, , Faiyaz Notta
This study analyzes ctDNA shedding in pancreatic cancer using paired tissue and plasma whole genomes, finding that subclones contribute significantly to early dissemination and ctDNA levels.
bioRxiv · Nov 27, 2025 · PreprintCancer Biology