Brendon Seale

The paper improves library construction for low-input proteomics by using reference samples, showing significant performance gains in both OpenSWATH and DIA-NN workflows.

This study benchmarks ten proximity ligases across cellular compartments and time windows, finding variations in activity, background, and spatial specificity, with ultraID showing the best balance.

This study integrates spatial proteomics and genomics in PDAC to identify tumour-immune-stroma interactions and their genomic associations, showing multi-omics models improve patient survival prediction.

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

The paper introduces ecTurboID, a method to profile extracellular protein interactions, identifying LDLR as a new EGF-dependent EGFR partner.