Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice
Allain-Thibeault Le Sourd Ferhat, Elisabeth Verpy, Anne Biton, Benoît Forget, Fabrice de Chaumont, Florian Mueller, Le Sourd Anne-Marie, Sabrina Coqueran, Julien Schmitt, Christelle Rochefort, Laure Rondi‐Reig, Aziliz Leboucher, Anne Boland, Bertrand Fin, Jean‐François Deleuze, , Thomas Bourgeron
This study identifies gene dysregulation and striosome-matrix imbalance in Shank3 mutant mice, linking these changes to behavioral abnormalities associated with autism.
bioRxiv · Jan 19, 2022 · PreprintNeuroscience