Anne Biton

This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.

The paper introduces a framework for multimodal chemical screens combining RNA, protein, and epigenomic readouts, revealing compound-specific mechanisms and off-target effects in T cells.

BioConvert simplifies life science data format conversion by aggregating tools and providing a unified interface, supporting 50 formats and 100 conversions.

This study identifies gene dysregulation and striosome-matrix imbalance in Shank3 mutant mice, linking these changes to behavioral abnormalities associated with autism.

The paper uses a massively parallel reporter assay to analyze 3' UTR sequences and shows that ARE length and registration affect mRNA stability and gene expression.

The paper identifies a species-specific retrotransposon promoter that generates a conserved Cdk2ap1 isoform essential for preimplantation development across mammals.

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

MPRAudit quantifies the fraction of variance explained by unknown features in MPRA data, revealing sequence variation as the main driver of outcome variability but with known categories explaining only part of the variance.

This paper introduces multi-level barcoding to address clonal heterogeneity in pooled genetic screens and demonstrates its ability to resolve cellular heterogeneity issues.

The paper introduces an orthogonal CRISPR/Cas screen to systematically activate one gene while knocking out another, enabling the identification and directionality of genetic interactions in human cancer cells.